Sugar acids and derivatives
Medchemexpress LLC Homo-PROTAC pVHL30 degrader 1 | 2244684-49-7 | 99.4% | 1179.45 | 25 MG
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consisting of two ligands of von Hippel-Lindau. It dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response. This product is for research use only.
- Dimerizes von Hippel-Lindau (VHL) with high avidity in vitro.
- Induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
- Acts in a highly isoform-selective fashion.
- Does not trigger a hypoxic response.
Medchemexpress LLC Intestinal Alkaline Phosphatase Antibody (YA1559) | 10 UL
The Intestinal Alkaline Phosphatase Antibody (YA1559) is a rabbit-derived, non-conjugated IgG monoclonal antibody designed to target Intestinal Alkaline Phosphatase. This enzyme is a key component of the gut mucosal defense system, functioning in the detoxification of lipopolysaccharide and preventing bacterial translocation within the gut. It can hydrolyze various phosphate compounds and is localized to the cell membrane as a homodimer.
- Derived from rabbit
- Monoclonal and recombinant
- Non-conjugated
- Reacts with human samples
- Formulated in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- Liquid appearance
- Immunogen derived from human intestinal alkaline phosphatase
- Ships with blue ice
Medchemexpress LLC 6-(2-(2,4-Difluorophenoxy)-5-((ethylsulfonyl)methyl)pyridin-3-yl)-8-methylpyrrolo[1,2-a]pyrazin-1(2H)-one | 2411226-02-1 | 99.7% | 10 MM * 1 ML
BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. It binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). This inhibitor also demonstrates anti-cancer activity.
- Orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor.
- Binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities.
- Exhibits anti-cancer activity.
- Demonstrates antiproliferative activity against various human leukemia and myeloma cell lines.
- Induces G1-phase cell cycle arrest and reduces c-Myc, BCL-2, and CDK6 expressions in MV-4-11 cells.
- Offers high selectivity for the BET bromodomain family.
- Shows strong antitumor activities in an MV4-11 mouse xenograft model.
Medchemexpress LLC BET bromodomain inhibitor 1 | 2411226-02-1 | 99.7% | 25 MG
BET bromodomain inhibitor 1 is an orally active and selective inhibitor of bromodomain and extra-terminal (BET) bromodomains. It demonstrates anti-cancer activity by inducing G1-phase cell cycle arrest, inhibiting c-Myc expression, and upregulating p21 levels. Its primary applications involve research into acute myeloid leukemia, acute leukemia, and multiple myeloma.
- Orally active and selective BET bromodomain inhibitor.
- High affinity for BRD4 (IC50: 2.6 nM) and other BET bromodomains.
- Demonstrates anti-cancer activity by inducing G1-phase cell cycle arrest.
- Effective against various cancer cell lines (Kasumi 1, MM1.S, MV4-11, and RS4-11).
- Excellent selectivity for BET bromodomain family over other bromodomains.
- Does not inhibit five cytochrome P450 enzymes.
- Exhibits strong antitumor activities in in-vivo models.
eMolecules Ambeed -D-glucuronide-pNP-carbonate 100mg 847281787 A1365593 0 000 894095-98-8 913 842 C45H43N3O18
Ambeed -D-glucuronide-pNP-carbonate 100mg 847281787 A1365593 0 000 894095-98-8 913 842 C45H43N3O18
Gold Biotechnology Inc NADH Beta Reduced Sodium Salt
Reduced -nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation NADH is a required oxidizing cosubstrate in fermentation which regenerates NADH is fluorescent which provides for a relatively simple way to detect NADH in biological samples NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues
Gold Biotechnology Inc NADH Beta Reduced Sodium Salt
Reduced -nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation NADH is a required oxidizing cosubstrate in fermentation which regenerates NADH is fluorescent which provides for a relatively simple way to detect NADH in biological samples NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues
Medchemexpress LLC D-praziquanamine ((-)-praziquanamine) | 55375-92-3 | MFCD30491837 | 98.9% | 202.26 g/mol | C12H14N2O | 10 MG
D-Praziquanamine ((-)-praziquanamine) is the stereoisomer of L-praziquanamine, provided as a research reagent for use as an experimental control in biochemical and pharmacological studies.
- Isomer of L-praziquanamine, intended for use as an experimental control.
- CAS number 55375-92-3.
- Molecular formula C12H14N2O, molecular weight 202.26 g/mol.
- Typical purity ~98.9% (batch-specific; see certificate of analysis for details).
- Appearance: solid; also offered as a 10 mM solution in DMSO.
- Available in small sample sizes and milligram-scale quantities (for example, 10 mg).
Medchemexpress LLC Bet-bay 002 | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 100MG
BET-BAY 002 is a small-molecule BET bromodomain inhibitor intended for research use. It demonstrates activity in multiple myeloma models and is provided as a high-purity solid for in vitro and preclinical studies. The compound is soluble in DMSO and is offered in multiple pack sizes to support assay development and screening.
- Potent BET bromodomain inhibitor with reported efficacy in multiple myeloma models.
- High purity (99.8%) suitable for biological assays.
- Soluble in DMSO for convenient reconstitution.
- Available in multiple quantities including a 100 mg package.
- Molecular weight 403.86 g/mol and formula C22H18ClN5O.
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (hFc-tagged) | 20UG
Recombinant heterodimeric integrin alpha V beta 3 protein derived from mouse, produced in HEK293 cells and fused to a C-terminal human Fc (hFc) tag. Supplied as a 20 μg research reagent, it is intended for receptor-ligand interaction studies, cell adhesion assays, and signaling investigations.
- Recombinant heterodimeric integrin alpha V beta 3 derived from mouse
- Expressed in HEK293 cells to support mammalian post-translational modifications
- C-terminal human Fc (hFc) tag for purification and detection
- Suitable for receptor-ligand binding, cell adhesion, and signaling assays
- Molecular weight ranges reported for subunits: 110-135 kDa and 50-60 kDa
- Supplied as a 20 μg unit for laboratory research use
Medchemexpress LLC 4-Methylumbelliferyl β-D-cellobioside | 72626-61-0 | MFCD00063279 | 99.4% | 500.45 | 100 MG
4-Methylumbelliferyl β-D-cellobioside is a substrate for cellulase. It can be hydrolyzed to produce fluorescent 4-methylumbelliferone, which is used to study the kinetics of cellulases.
- Substrate for cellulase
- Produces fluorescent 4-methylumbelliferone
- Used to study the kinetics of cellulases
Medchemexpress LLC Integrin alpha V beta 3 protein | >95.0% | 100UG
Recombinant mouse integrin αVβ3 heterodimer, biotinylated and expressed in HEK293 cells with C-terminal His and Avi tags; supplied for biochemical and cell-based assays including binding studies and immobilization.
- Biotinylated for detection and streptavidin-based immobilization.
- Expressed in mammalian cells to preserve native folding and post-translational modifications.
- His and Avi tags facilitate purification and biotinylation workflows.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Suitable for ELISA, surface plasmon resonance, and receptor binding assays.
- Store at -20°C and freeze aliquots for extended storage.
Medchemexpress LLC Complement factor D-IN-1 | 1386455-76-0 | 98.9% | 483.32 g/mol | C21H19BrN6O3 | 25 MG
Complement factor D-IN-1 is a potent and selective reversible small-molecule inhibitor of complement factor D used in research to probe the alternative complement pathway. It exhibits low-nanomolar activity in biochemical assays and is supplied with high reported purity as a solid or as a DMSO solution.
- Potent and selective reversible inhibitor of complement factor D.
- Demonstrated low-nanomolar IC50s in FD thioesterolytic and MAC deposition assays.
- High reported purity (≈98.8%).
- Available as dry powder or as a ready-to-use DMSO solution.
- Stable when stored under recommended conditions for long-term use.
- Suitable for biochemical and cellular complement pathway studies.
Cayman Chemical D-GlucuronIc AcId 5g
A metabolite of glucose; a component of proteoglycans; levels are increased in fibroblasts isolated from patients with ISSD or Salla disease
Medchemexpress LLC IL-1RA/IL-1F3 Porci 5ug | 5ug
IL-1RA/IL-1F3 proteins are powerful anti-inflammatory antagonists in the interleukin 1 family specifically targeting the pro-inflammatory cytokines IL1B and IL1A This protein counteracts the inflammatory effects of IL1 playing a critical role in preventing immune dysregulation and preventing uncontrolled systemic inflammation triggered by a variety of innate irritants including pathogens IL-1RA/IL-1F3 Protein Porcine is the recombinant Porcine-derived IL-1RA/IL-1F3 protein expressed by E coli with tag free